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What is the reason for using the 900ml of dissolution medium
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Answer Posted / swayamprakash patel
I laughed lot after reading all stupid answers...
Any ways...
whole criteria of selecting volume of tablet dissolution is
SINK CONDITION.
One have to select dissolution media from normal
physiological pH range. Moreover, volume of dissolution
media must create sink condition.
For creating sink condition, volume of media must be at
least 3 times (or more than 3) the maximum dose/solubility
ratio of drug.
For most of drug 900 ml fulfill this criteria. However there
are some drug which need 1000ml (eg:Fenofibrate). while for
some drugs 500ml is enough.
That is what exactly the reason.
Need further clarification: go to following link
http://www.dissolutiontech.com/DTresour/201211Articles/DT201211_QA.html
Volume of stomach is more than 900 ml...But this answer is
totally stupid...I mean how many patients drink about a 1
liter water with single tablet?....HA HA HA...
| Is This Answer Correct ? | 41 Yes | 11 No |
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