Answer Posted / roshan bhaskar

cleaning validation means washing of vessel with suitable reangent i.e it may be water,chloroform,isopropyl alcohol.

in rinse we take sample from outlet of vessel for analysis.

swab- in swab we take sample with help of swab stick where we not reached to take sample from vessel. mostly we take swab for cream ointments.

In HPLC calibration, caffeine is used as primary standard for wave length calibration due to caffeine is having dual maxima at 273 & 205 nm and one minima at 245 nm. Any body can give reference of these details from any pharmacopeia (with chapter no.) or any other authentic guideline?

2015

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what is mean by covalidation

830

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why octanol used to determine the partition coefficient ?

2497

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A ha tc is actual defination of retention time?

1662

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on the basis of bcs class how to proceed the solubility?

831

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How we performed the force degradation for drug substance, is any specific guideline is available for each parameter(Acidic, basic, oxidation,heat)? what conditions you mentained for above parameters.

2359

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Why potassium dichromate is used in calibration of uv?

2038

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acceptance criteria for lod & loq by standard deviation of response and slope??

2642

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How to start the dissolution development for unknown tab?

1739

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why does used dry caffien in HPLC calibration?

2079

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What is the difference between Discriminating media and DPDM(Dissolution Profile with Different Media)

7604

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when we talk about change in entropy we consider total entropy means of surround +entropy of system but when we talk about change in Gibss free energy we consider entropy of system.explain with reason.

2096

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how will you do the prep for unstable componds?

2068

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in which situation require to use paddle and basket?

794

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if your product is soluble in 0.1n hcl and water then which you choose as media from these 2 media?

735

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