Answer Posted / kiranmadineni

the media volume shold be more than 3 times of the drug
dosage saturation amount. that maybe 500ml,900ml,1000ml.

How can we confirm the HPLC column is end-capped or not? Is it possible to identify by physical appearance?

3152

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WHAT IS THE CRITERIA FOR SELECTION OF TIME OF DISSOLUTION AND THE MEDIUM OF DISSOLUTION?

2523

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calibrtion procedue of LC-MS

2664

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Difference between the quantitative analysis and qualitative analysis?

1103

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UV and PDA detector, which have less signal to noise ratio?

1081

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In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.

3065

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If change in specification which parameter require to do for validation? if change in chromtographic condition then which parameter? if api change then which parameter? if change composition then which parameter? if old method not work out then whicj parameter? if additional one impurity added then which parameter of validation require to do on above each conditions? elaborate separately

795

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What is related substance by HPLC impurity limits as per USP?

1030

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What are usp limits for theoritical plats,resoution,tailing factor,peak to valley ratio

1848

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in monograph 7 imp are there but in vendor showing 5 imp do not req to include 2 imp for that what will be justification?

664

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How doing qbd practically?

914

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How to know the estimated LOQ concentration in ppm

1153

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how will you do the prep for unstable componds?

1971

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What is delay volume?

1325

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In IR spectra, generally a molecule vibrates without apply emr or ir light?

1906

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