Answer Posted / venkata padmanabheswara rao

Primary Standard:
A substance that is widely acknowledged to have the
appropriate characteristics within a specified context and
whose value is accepted without requiring comparison to
another substance, this substance should be obtained from
official recognized sources.

Secondary
A substance of established quality and purity as shown by
comparison to a Primary standard used as a Secondary
standard for routine laboratory analysis. It serves as a
substitute for its corresponding Primary standard.

In BP2013, Loperamid HCl monograph. Assay by titration with 0.1N sodium hydroxide using hydrocloric acid 0.01N and reading the volume added between the 2 points of inflexion. I have a question that if the diluent solvent is ethanol is certainly consumed a amount of volume of titrant, so this volume must be eliminated on the result calculation or not apart from first point which is subtracted above.

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