How to calculate LOD & LOQ in HPLC Validation Method

Answer Posted / dr.praveen choubey

by HPLC LOD @ LOQ calculated by S/N ratio that is the best
method.LOD s/N NLT 3 and LOQ S/N NLT 10 and also calculated
by visual evalution.

Is This Answer Correct ?    11 Yes 2 No



Post New Answer       View All Answers


Please Help Members By Posting Answers For Below Questions

How can the GC or HPLC method is selected to determine the impurity profile in drug product?

6860


why octanol used to determine the partition coefficient ?

1920


what are the guidelines for analytical method validations?

593


Why six unit used for precision?

798


What is shaking level in GC?

330






how require to select dissolution media? what is discrimination?

314


how much mass should be there in volumetric flask while in preparation of sample for assay? 

2059


Ph meter can show more than 14 ph reading? Why ph range in between 1 to 14 only?

303


How we can identify process related and degradation impurity in single method with short period?

329


is it necessary to do HPLC calibration at wavelength 315nm if we are doing analysis at this wavelangth

1661


HI,I CLEARED BOB CLERK EXAM. MY INTERVIEW WILL BE ON 9TH OCTOBER,2010.PLEASE SEND ME INTERVIEW QUESTIONS AND ANSWERS. THANK YOU.

1734


how you confirm the assay method?

285


why cone formation during dissolution?

323


how many types of balance calibration test?

1727


We use Potassium Dichromate solution for the calibration of UV-Visible Spectrophotometer in UV region. My question is to calibrate visible region which solution could be used in photometric accuracy

1317