Answer Posted / swapnil borse

Packed columns have higher sample capacity than capillary
columns, although the difference has been greatly reduced by
the large-bore 530µm capillaries invented by Agilent.
Improvements in detector sensitivity have also reduced the
need for large samples. The one area in which packed columns
may have an advantage is in analysis of gas samples.

For almost all other samples, capillaries provide much
better efficiency (narrow peaks) which leads to greatly
improved peak separation. In fact, the separating power is
so great that many analyses can be done on surprisingly
short columns in very brief runs. This time saving
translates directly into reduced turnaround time and
increased sample throughput.

For new or updated methods, we recommend capillary columns
unless there is some overwhelming reason for using packed
columns.

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