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What is discriminating media? How can u justify/select that
which media (pH etc...)is suitable for your dissolution study
of your compound?
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Answer Posted / bhupal24
A releasing medium is the one that promotes solubilization
of the drug substance from a pharmaceutical dosage form
without further qualification. A discriminating medium is
the one where the more subtle aspects of the pharmaceutical
dosage form can be differentiated by observing their
individual rates of dissolution. Particle size,crystal
form,salt form,presence of water of hydration,differences
in the manufacturing processes,and so forth,may all affect
the dissolution performance.The dissolution test should be
sensitive to any attribute that may affect the in vivo
performance of the product.
| Is This Answer Correct ? | 4 Yes | 7 No |
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