How to calculate LOD & LOQ in HPLC Validation Method
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Answer Posted / sunil.madhukar rao kulkarni
We can calculate LOD and LOQ values using linearity
graph,insted of sigma value STEYX can be considered for
more acuurate vale of LOD and LOQ
where STEYX : Standard error of the pridected Y-value for
each X in a regression
Final calulation given as below :
LOD = STEYX x 3/ Slope
LOQ = STEYX x 10 /Slope
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