Answer Posted / ananthan chandrasekar

LOD-Limit of detection.It is the lowest amount of the
analyte that can be detected and not necessary to be
quatitated.

LOQ-Limit of Quantitation. It is the lowest amount of the
analyte that can be detected and quantified.

If u get the impurity value below LOD, impurity result can
be declared as BDL(Below detection limit)

If u get the impurity value morethan LOD value but lessthan
LOQ value,impurity result can be declared as BQL(Below
Quantitation limit)

Only those impurities which are exceeding LOQ value to be
declared as per calculated value and this value canbe
included for Total impurity calculation.
For reference, See the example
Impurity LOD LOQ Calculated value Result
A 0.002% 0.006 % 0.001% BDL
B 0.002% 0.006 % 0.003% BQL
C 0.002% 0.006 % 0.008% 0.008%
D 0.002% 0.006 % 0.009% 0.009%
Total impurity = 0.008% +0.009 % =0.017%

iam usig ph buffers merk. manually how to prepare ?

1875

---

Hi sir if any product monograph not given known impurities (may be 5 impurities) specifications then how we require to proceed for inhouse formulation?

373

---

How do we quantify crystaline and amarpous forms by using (NMR, XRD)spectroscopic techniques? Which any others instruments are useful for this quantification? explain

2043

---

if peak get problamatic then what require to do?

416

---

WHY given much noise PDA dector then VWD Dector

1590

---

---

if you have given a blank water how you analyse by general analytical techniques?

1609

---

What is Band broading effect explain

1486

---

Which type of column should i use to check the purity of high molecular weight protein using HPLC reverse phase column chromatography? Hi everyone. I wanna to check the purity of high molecular weight protein (collagen) with MW of ~130 kDa using a HPLC. I know C18

1556

---

What is mean by PDR?

429

---

How to determine water content of bis tetrazole amine mono ammonium salt

3058

---

what is the different in Total ash, sulphated ash, acid insoluble ash, alcoholic or non alcoholic ash?

9561

---

give clarity of linearity and range in method validation

2016

---

how can give the expiry period and restadardisation of volumetric solution

2169

---

WHAT IS THE PURPOSE WE USE HCL, CHOPPER, BURNER, MONOCHROMATOR in AAS? PLEASE EXPLAIN BRIEFLY

2222

---

In the HPLC Calibration done wavelength accuracy done between 200nm-280nm .but not done remaining 300-400nm not done ?

566

---