why the most API molecule are in the hydrochloride form?
Answer Posted / mr.shoukatalli naikwade
API molecule without hydrocloride salts are in the form of
base and it is higly non polar.its solubility in water as
well as in our blood and gastric juices in stomach is very
poor.
Our pH of stomach is arround 2 and gastric acid consisting
mainly of hydrochloric acid 0.5%.
To increase API's solubility of drugs,salt formation plays
important role in dissolution and dis integration of tablet.
for salt formation hydrochloric acid is mostly choosed.
Is This Answer Correct ? | 27 Yes | 0 No |
Post New Answer View All Answers
What is the accrptance criteria in RSD for RS method precision on basis of impurity percentages?
EXPLAIN THE CALCULATION PART OF AN KF TITRATOR CALIBRATION WITH SUITABLE EXAMPLE
what is %labelled amount in content uniformity of dosage unit and its calculation?
How to set specification of assay, fisdolution and related substances?
Principle of single pan analytical balance
WHAT IS THE PARAMETER FOR THE SELECTION OF MOBILE PHASE IN HPLC?
USP methodology, EP methodology, IP methodology, among three if possible to use one methodology for qualify working standard to use USP, EP, IP ? Please explain...
why require to add enzymes in capsules dissolution only? is it require to tablet also?
for inorganic molecules require to do RS, Assay and disso?
how much mass should be there in volumetric flask while in preparation of sample for assay?
How to set analyticl specification for combination products?
why we use a particular hplc column for a particular compound give reasons?please
1)What's the meaning of Absorption,give a example. 2)What's the meaning of Adsorption,give a example. 2)what is the difference between Absorption and Adsorption.
What is the difference between spectro meter and spectro photo meter?
how you establish the LOQ?