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Explain the basic structure of collagen?
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Answer / swapna
Collagen is a major fibous protine of extracellular
connective tissues, and it is also the most ubiquitous and
pletiful In the animal Kingdom. Some 25-35% of body protein
is collagen.
Collagen fibers gives strengh and structure to tissue in
the body. Fibroblast cell produce collagen which from
tissue structure and they contain collagen fibers arranged
in three dimentions.
Fibrils are smaller units of collagen fibers which are made
of a repeating pattern of collagen molecules. The gaps and
overlapping region between the molecules are specific, the
gaps are there where the molecules may be cross linked.
The collagen molecule is a rigid rod 2900A0 by 15A0 ,triple
helical structure. The major portion consists of three
amnioacid chains, each in a left handed delical
conformation to make on super helix molecule with frayed
non helical ends.
Charaterised by repetitive Gly-X-Y sequences where glycine
is In every third residue, and stabilized by proline and
hydroxyproline resiues. Glycine has the hydrogen atom, the
only element small enough to fit in the center of the super
helix.
There are various 13 types of collagen Identified and they
are characterized collagen are type 1 and type 3.
Collagen present in the body gives strength and structure
to the tissues.In hard tissues inckuding bone, collagen
functions to provide supports.
In soft tissues, collgen matrix gives from and Integrity to
tissues, In cardiovascular tissues, collagen froms a stiff
layer that allow the artery a maximum exansion beyond which
the artery would burst, thus providing protection.
| Is This Answer Correct ? | 4 Yes | 0 No |
Answer / madhukar
Collagen has an unusual [[amino acid]] composition and
sequence:
* [[Glycine]] (Gly) is found at almost every third
[[residue (chemistry)|residue]]
* [[Proline]] (Pro) makes up about 9% of collagen
* Collagen contains two uncommon derivative amino acids not
directly inserted during [[translation (genetics)
|translation]]. These amino acids are found at specific
locations relative to glycine and are modified post-
translationally by different enzymes, both of which require
[[vitamin C]] as a [[cofactor (biochemistry)|cofactor]].
** [[Hydroxyproline]] (Hyp), derived from proline.
** [[Hydroxylysine]], derived from [[lysine]]. Depending on
the type of collagen, varying numbers of hydroxylysines
have [[disaccharide]]s attached to them.
| Is This Answer Correct ? | 1 Yes | 0 No |
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