Answer / aditi

In purified water the solubility of chloramphenicol is only
0.25%.
Several approaches such as pH adjustment, complexation ,
micellar solubilization , cosolvency were successfully
employed to enhance the solubility. The present market and
official preparations contain chloramphenicol in water, the
pH adjusted with boric acid/borax buffer to enhance to the
required solubility (5 mg/ml). Similarly, when the pH is
raised to 8.6, its solubility reaches to 1%. However, the
stability and activity are much reduced.

Solubility of non-ionizable substances can be enhanced by
the addition of non polar solvents and when mixture of
solvents such as PEG 300 are used along with water, the
technique is generally termed as cosolvency techinque.

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