What are the differences between GC and HPLC?

Question Posted / kalaiselvan a

1 Answers
15237 Views
I also Faced
E-Mail Answers

What are the differences between GC and HPLC?..

Answer / g. subrahmanyam

The difference between HPLC and GC are as follows.
a. In HPLC the mobile phase is a liquid whereas in Gas
Chromatography the mobile phase or carrier is a gas.
b. HPLC is useful for analysis of samples which are
liable to decompose at higher temperatures. GC involves high
temperatures, so compounds are stable at such temperatures.
c. Gas Chromatography is applied for analysis of
volatile compounds whereas non volatile compounds can be
easily analyzed on HPLC
d. Gas Chromatography cannot be used for analysis of
high molecular weight molecules whereas HPLC has
applications for separation and identification of very high
molecular weight compounds
e. HPLC requires higher operating pressures than GC
because liquids require higher pressures than gases for
transport through the system
f. HPLC columns are short and wide in comparison to GC
columns

Is This Answer Correct ?

34 Yes

0 No

Post New Answer

More Analytical Chemistry Interview Questions

What is post run in hplc?

1 Answers Cipla,

WHEN AN UN KNOWN SAMPLE IS GIVEN TO U,HOW WILL U START THE ANALYSIS(ie FIRST WHICH TEST TO BE DONE,NEXT,THEN NEXT),HOW WILL U DECIDE WHICH TYPE OF ANALYSIS TO BE DONE FOR IT?

2 Answers Aurobindo,

Why caffeine as a reference standard used for calibration of HPLC?

11 Answers Gangwal Chemicals, Orchid,

what is partion and column chromatography

0 Answers Emcure,

how can you do the analysis of compound given to u by hplc

2 Answers

water is more polar than acetonitrile.but in reverse phase chromatography peaks elute earlier when we increse Acetonitrile.what is the reason.

10 Answers Matrix,

why we get only one peak in assay by hplc but in rs by hplc get more peaks

1 Answers MSN Pharma,

Difference between related substances & impurities