Difference Between Purity And Potency?

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Difference Between Purity And Potency?..

purity is the absence of impurities or contaminants in a substance

potency is the term used to express the effect of drug.potency is the amount of drug required to show effect of given intensity
highly potent drugs shows a larger effect at low concentrations .
potency of a drug directly proportional to purity

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Difference Between Purity And Potency?..

Answer / navinpatel

Potency is a measure of drug activity expressed in terms of
the amount of drug required to produce an effect
(Physiological, Therapeutical, Inhibitor) of given
intensity. A highly potent drug (e.g., morphine) produce a
greater response at low concentrations, while a drug of
lower potency (ibuprofen, acetylsalicylic acid) produce a
small response at low concentrations.

Purity is the absence of unwanted substance either impurity
or contaminants. Purity is one of the most important
parameters considered in pharmaceutical products. More pure
the substance more is the activity.

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Difference Between Purity And Potency?..

Answer / naveen gutta

Purity:

It is calculated by area normalisation method, it can be directly find out by chromatograms obtained from HPLC.

% Purity = (Area of desired peak / Sum of area of all peaks) x 100

Assay:

It is calculated against standard. It may be of following types:

1) On as is basis = (Area of sample / Area of standard) x (conc. of standard / conc. of sample) x potency or assay of standard
2) On anhydrous basis = (Assay on as is basis / 100 – moisture) x 100
3) On dried basis = (Assay on as is basis / 100 – LOD) x 100

Potency:

100 – (moisture or LOD + residual solvents + heavy metals + sulphated ash + impurities)

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