What is difference between Chromatographic purity and
Related substances analysis?
Answers were Sorted based on User's Feedback
Answer / arumugam
chromatographic purity is %area normalization is nothing
but Impurity area/Major compound area, applicable for all
known and unknown impurities.
But Related substances is quantification of all impurities
nothing but the impurities are quantified by know
concentration of standard solution.
Impurity (%w/w)= Imp area* Std. Dilution*Potency of Std*RRF
------------------------
Std Area* sample Dilution
RRF= Relative Response factor
Is This Answer Correct ? | 27 Yes | 1 No |
Answer / gayathri
Chromatographic purity is a qualitative analysis and Related substances is a quantitative analysis
Is This Answer Correct ? | 6 Yes | 5 No |
Answer / amol
chrom purtiy is used when all the impurity is known and in
related substances used for both known as well as unknown
impurtiy
Is This Answer Correct ? | 8 Yes | 21 No |
what is use of acetonitrile compare to methanol in RP-HPLC Method devlopment
How to calibration of the uv spectroscopy and its test?
What is the SOP for SOP
What is FDA form 482c?
What r the limitatoins of uv visible spectroscopy ? Why Water use in blank standard for uv visible spectroscopy ?
why are using toluene in uv calibraion in resolution performance
During Validation study, Recovery is passing at all levels but Linearity is failing. Justify?
1 Answers Mylan, Torrent Pharma,
what is the meaning of ventillation in HPLC?
3 Answers Amneal Pharmaceuticals,
Why we are using the methanol in Kf titration?
some product having water content method with pyridine and ethylene glycol mixture instead of methanol? how they are selecting and methanol is not suitable solvent how ?
why we use only six bowls for dissolution of a drug
1 Answers Cipla, Natco, TelePerformance,
How to decide restandardisation due or retest or expiry of Volumetric solutions prepared in wet chemistry lab?