Difference between c18
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Answer Posted / mr. bujji reddy kanchi
the difference between these two columns is packing only
C18- octa decyl chain linked to silica.
c8- only octyl chain linked to silica.
C18 is widely used, the polymeric C18 format incorporates a
tri-functional silylation procedure whereby the octadecyl
group is bonded to 2 or 3 silica atoms on the silica gel
backbone. This increased silylation results in far greater
column stability particularly in acidic mobile phase
conditions. Stereo recognition capability is also greater
than that of the monofunctional silylation type of C18.
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